Endocrine Abstracts

Case history: A 50 year old female presented with diarrhoea, facial rash and hyponatraemia. In addition, she described a 3 week history of headaches, malaise, intermittent joint pain and swelling. On examination, the patient was noted to have a malar rash and over the subsequent 2–3 days began to develop necrotic patches on both ears. She had no evidence of cutaneous pigmentation. She took no regular medication, other than dabigatran. Past medical history of note included...

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder caused by 21-hydroxylase deficiency in 95% of all cases. Two main clinical subtypes: the classical (manifested after birth, or in early newborn period) and the late onset (LO) phenotype (manifested commonly during puberty). The lifelong glucocorticoid (GC) supplementation is essential in therapy of these patients. Response to GC therapy is individual and partly genetically determined....

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. In recent years, two prognostic scoring systems incorporating relevant clinicopathological features of ACC (ENSAT stage, grade, resection status, age at diagnosis, tumour symptoms) have been proposed: the GRAS and S-GRAS scoring systems. The prognostic value of these systems has been demonstrated in large, multicentre studies.Aim: To su mmarize the clinicopathological f...

Introduction: Clinicopathological characterisation ofneuroendocrine neoplasms could provide improved prognostic information even at the time of the diagnosis.Objectives: The aim of this study was to characterise the clinicopathological features of a large cohort of patients with neuroendocrine neoplasms (NENs).Patients and methods: The study included 210 patients (95 men and 115 women) with histologically confirmed and verified neu...